2007 | 2006 | 2005 |2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 | 1992 | 1991 | 1990

2007Top

Song, K., Hornak, V., de los Santos, C., Grollman, A. & Simmerling, C.   Molecular Mechanics Parameters for the FapydG DNA lesion J. Comput. Chem. 2007 29, 17-23.

Song K., Kelso C., de los Santos C., Grollman A.P. & Simmerling C. Molecular simulations reveal a common binding mode for glycosylase binding of oxidatively damaged DNA lesions. J Am Chem Soc. 2007 129, 14536-14537

Grollman AP, Shibutani S, Moriya M, Miller F, Wu L, Moll U, Suzuki N, Fernandes A, Rosenquist T, Medverec Z, Jakovina K, Brdar B, Slade N, Turesky RJ, Goodenough AK, Rieger R, Vukelić M, Jelaković B.   Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proc Natl Acad Sci U S A. 2007 104(29):12129-34.

Grollman AP, Jelaković B. Role of environmental toxins in endemic (Balkan) nephropathy. J Am Soc Nephrol. 2007 18(11):2817-23.

Blumenberg M, Gao S, Dickman K, Grollman AP, Bottinger EP, Zavadil J. Chromatin structure regulation in transforming growth factor-beta-directed epithelial-mesenchymal transition. Cells Tissues Organs. 2007;185(1-3):162-74.

Shibutani S, Dong H, Suzuki N, Ueda S, Miller F, Grollman AP.   Selective toxicity of aristolochic acids I and II. Drug Metab Dispos. 2007 35(7):1217-22.

 
2006Top

Dong, F., Suzuki, N., Torres, M. C., Bonala, R. R., Johnson, F., Grollman, A. P., and Shibutani, S. Quantitative determination of aristolochic acid-derived DNA adducts in rats using 32P-postlabeling/polyacrylamide gel electrophoresis analysis. Drug Metab. Dispos. 34,1122-1127 (2006).

Dong H, Suzuki N, Torres MC, Bonala RR, Johnson F, Grollman AP, Shibutani S. Quantitative determination of aristolochic acid-derived DNA adducts in rats using 32P-postlabeling/polyacrylamide gel electrophoresis analysis. Drug Metab Dispos. 34, 1122-7 2006)

Rieger, R. A.; Zaika, E. I.; Xie, W.; Johnson, F.; Grollman, A. P.; Iden, C. R.; Zharkov, D. O. Proteomic Approach to Identification of Proteins Reactive for Abasic Sites in DNA, Mol. Cell Proteomics, 2006, , 858-867.

Stein S., Lao Y., Yang I.-Y., +Hecht S.S., and Moriya M., Genotoxicity of acetaldehyde- and crotonaldehyde-induced 1,N2-propanodeoxyguanosine DNA adducts in human cells, Mutat. Res. 2006, 608: 1-7.

Pollack M., Yang I.-Y., Kim H.-Y. H., Blair I.A., and Moriya M., Translesion DNA synthesis across the heptanone-etheno-2’-deoxycytidine adduct: unique coding events in bacteria and human cells, Chem Res. Toxicol. 2006, 19: 1074-1079.

Liu, X., Lao, Y., Yang, I.-Y., Hecht, S.S., and Moriya, M., Replication-coupled repair of crotonaldehyde/acetaldehyde-induced guanine-guanine interstrand cross-links and their mutagenicity, Biochemistry 2006, 45: 12898-129056.

Kalam, M.A., Haraguchi, K., Chandani, S., Loechler, E.L., Moriya, M., Greenberg, M.M. and Basu, A.K., Genetic effects of oxidative DNA damages: comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells, Nucleic Acids Res. 2006, 34: 2305-2315.

Song, K., Hornak, V., de los Santos, C., Grollman, A. & Simmerling, C. Computational analysis of the binding mode of 8-oxo-guanine to formamidopyrimidine-DNA glycosylase Biochemistry 2006, 45: 10886-10894.

Liu X, Lao Y, Yang IY, Hecht SS, Moriya M. Replication-coupled repair of crotonaldehyde/acetaldehyde-induced guanine-guanine interstrand cross-links and their mutagenicity. Biochemistry. 2006 45(42):12898-905.

Pollack M, Yang IY, Kim HY, Blair IA, Moriya M. Translesion DNA Synthesis across the heptanone--etheno-2'-deoxycytidine adduct in cells. Chem Res Toxicol. 2006 19(8):1074-9.

Stein S, Lao Y, Yang IY, Hecht SS, Moriya M. Genotoxicity of acetaldehyde- and crotonaldehyde-induced 1,N2-propanodeoxyguanosine DNA adducts in human cells. Mutat Res. 2006 608(1):1-7.

Kropachev KY, Zharkov DO, Grollman AP. Catalytic mechanism of Escherichia coli endonuclease VIII: roles of the intercalation loop and the zinc finger. Biochemistry. 2006 45(39):12039-49.

Song K, Hornak V, de Los Santos C, Grollman AP, Simmerling C.   Computational analysis of the mode of binding of 8-oxoguanine to formamidopyrimidine-DNA glycosylase. Biochemistry. 2006 45(36):10886-94.

Golan G, Zharkov DO, Grollman AP, Dodson ML, McCullough AK, Lloyd RS, Shoham G. Structure of T4 pyrimidine dimer glycosylase in a reduced imine covalent complex with abasic site-containing DNA. J Mol Biol. 2006 362(2):241-58.

Gening LV, Klincheva SA, Reshetnjak A, Grollman AP, Miller H. RNA aptamers selected against DNA polymerase beta inhibit the polymerase activities of DNA polymerases beta and kappa. Nucleic Acids Res. 2006 34(9):2579-86.

 

2005 Top

Tan X, Bonala RR, Suzuki N, Johnson F, Grollman AP, Shibutani S. Mutagenic specificity of 2-acetylaminonaphthalene-derived DNA adduct in mammalian cells. Chem Biol Interact 2005; 152: 131-138.

Shibutani, S., Kim, S. Y., and Suzuki, N. ³²P-Postlabeling DNA damage assay: PAGE, TLC and HPLC. In: DNA Repair Protocols: Eukaryotic systems, second edition. (Ed.) Daryl Henderson. Humana Press Inc. New Jersey, USA.. (2005)

Hranjec, T., Kovac, A., Kos, J., Mao, W., Chen, J. J., Grollman, A. P., and Jelakovic, B. Endemic nephropathy: the case for chronic poisoning by aristolochia. Croat. Med. J. 46, 116-125 (2005)

Cheng, X., Hornak, V., de los Santos, C., Grollman, A. P. & Simmerling, C. Dynamic behavior of DNA base pairs containing 8-oxoguanine. J. Am. Chem. Soc. 127: 13906-13918 (2005).

Conlon KA, Miller H, Rosenquist TA, Zharkov DO, Berrios M. The murine DNA glycosylase NEIL2 (mNEIL2) and human DNA polymerase beta bind microtubules in situ and in vitro. DNA Repair  4: 419-31 (2005).

Zharkov DO, Grollman AP. The DNA trackwalkers: principles of lesion search and recognition by DNA glycosylases. Mutat Res 33: 5006-16 (2005).

Golan G, Zharkov DO, Feinberg H, Fernandes AS, Zaika EI, Kycia JH, Grollman AP, Shoham G.   Structure of the uncomplexed DNA repair enzyme endonuclease VIII indicates significant interdomain flexibility. Nucleic Acids Res. 33(15):5006-16 (2005)

Grollman AP. Academic perspectives on dietary supplements use: the need for new guidelines. Thromb Res. 117(1-2):185-92 (2005)

Grollman AP, Simmerling C. Dynamic behavior of DNA base pairs containing 8-oxoguanine. J Am Chem Soc. 127(40):13906-18 (2005)

 

2004 Top

Kalam, M.A., Haraguchi, K., Alimchandani, S., Loechler, E.L., Moriya, M., Greenberg, M.M. and Basu, A.K., Comparative mutagenesis of Fapy•dG and 8-oxo-dG in mammalian cells, Biochemistry, submitted, 2004.

Suzuki, N., Itoh, I., Poon, K., Masutani, C., Hanaoka, F., Ohmori, H., Yoshizawa, I., and Shibutani, S. Translesion synthesis past estrogen-derived DNA adducts by human DNA polymerases. Biochemistry 43. 6304-6311 (2004). PDF

Kim, S. Y., Suzuki, N., Y. R. Santosh Laxmi, and Shibutani, S. Genotoxic mechanism of tamoxifen in developing endometrial cancer. Drug Metab. Rev. 36. 199-218 (2004).

Y. R. Santosh Laxmi, Suzuki, N., Kim, S. Y., and Shibutani, S. Synthesis of oligodeoxynucleotides containing a diastereoisomer of alpha-(N2-2’-deoxyguanosinyl)-N-desmethyltamoxifen. Bioorg. Med. Chem. Lett. 14. 4051-4054 (2004). PDF

Suzuki, N., Prabhu, M. P., and Shibutani, S. Detection of DNA adducts by 32P-postlabeling analyses. In: Optimization in Drug Discovery: In-vitro Methods, Yan, Z., and Caldwell, G. W. (Eds). Humana Press Inc. New Jersey, USA (2004) Humana Press Inc.

Miller H, Fernandes A, Zaika E, McTigue M, Torres C, Wente M, Iden C, Grollman A.P. Stereoselective excision of thymine glycol from oxidatively damaged DNA. Nucleic Acids Research. 2004; 32, No. 1: 338-45 PDF

Gola G, Zharkov D.O., Fernandes A.S., Zaika E, Kycia J.H., Wawrzak Z, Grollman A.P., Shoham G. Crystallization and preliminary crystallographic analysis of endonuclease VIII in its uncomplexed form. Acta Crystallographics, 2004, D60, 0 (in press)

Freisinger E, Grollman A.P., Miller H, Kisker, C. Lesion (in)tolerance reveals insights into DNA replication fidelity. EMBO, 2004; 23: 1494 -1505 PDF

Zaika E. I., Perlow R.A., Matz E, Broyde S, Gilboa R, Grollman A.P., Zharkov D.O. DNA: Replication, Repair and Recombination. J Biol Chem. 2004; 279: 4849 – 61 PDF

Polosina Y.Y., Rosenquist T.A., Grollman A.P., Miller H. “Knock down” of DNA polymerase ß by RNA interference: recapitulation of null phenotype. DNA Repair. 2004; (in press) PDF

Gao S., Chen J., Brodsky S.V., Huang H., Adler S., Lee J.H., Dhadwal N., Cohen-Gould L., Gross S.S., Goligorsky M.S. Docking of endothelial nitric oxide synthase (eNOS) to the mitochondrial outer membrane: a pentabasic amino acid sequence in the autoinhibitory domain of eNOS targets a proteinase K-cleavable peptide on the cytoplasmic face of mitochondria. J Biol Chem. 2004; 279(16):15968-74. PDF

2003 Top

Minetti, C.A.S.A., Remeta, D.P., Zharkov, D.O., Plum, G.E., Johnson, F., Grollman, A.P. and Breslauer, K.J. Energetics of Lesion Recognition by DNA Repair Protein: Thermodynamic Characterization of Formamidopyrimidine-glycosylase (Fpg) Interactions with Damaged DNA Duplexes. J. Mol. Biol. 2003; 328: 1047-1060 PDF

Zharkov, D., Shoham, G. and Grollman, A.P. Structural characterization of the Fpg family of DNA glycosylases.
DNA Repair. 2003; 2: 839 - 862 PDF

Freisinger, E., Fernandes, A., Grollman, A.P., and Kisker, C. Crystallographic Characterization of an Exocyclic DNA Adduct: 3, N4-etheno-2’-deoxyctydine in the Dodecamer 5’-CGCGAATT?CGCG-3’ J. Mol. Biol. 2003; 329: 685-697. PDF

Miller H, Grollman AP. DNA repair investigations using siRNA. DNA Repair (Amst). 2003 Jun 11;2(6):759-63. PDF

Rosenquist TA, Zaika E, Fernandes AS, Zharkov DO, Miller H, Grollman AP. The novel DNA glycosylase, NEIL1, protects mammalian cells from radiation-mediated cell death. DNA Repair (Amst). 2003 May 13;2(5):581-91. PDF

Krahn JM, Beard WA, Miller H, Grollman AP, Wilson SH. Structure of DNA polymerase Beta with the mutagenic DNA lesion 8-oxodeoxyguanine reveals structural insights into its coding potential. Structure (Camb). 2003 Jan;11(1):121-7. PDF

Yang IY, Miller H, Wang Z, Frank EG, Ohmori H, Hanaoka F, Moriya M. Mammalian translesion DNA synthesis across an acrolein-derived deoxyguanosine adduct. Participation of DNA polymerase eta in error-prone synthesis in human cells. J Biol Chem. 2003 Apr 18;278(16):13989-94. PDF

Yasui, M., Matsui, S., Y.R. Santosh Laxmi, Suzuki, N., Kim, S. Y., Shibutani, S. and Matsuda, T. Mutagenic events induced by 4-hydroxyequilin in supF shuttle vector plasmid propagated in human cells. Carcinogenesis 24, 911-917 (2003). PDF

Shibutani, S., Suzuki, N., Y. R. Santosh Laxmi, Schild, L. J., Divi, R. L., Grollman, A. P., and Poirier, M. C. Identification of tamoxifen-DNA adducts in monkeys treated with tamoxifen. Cancer Res. 63, 4402 - 4406 (2003). PDF

Kim, S. Y., Suzuki, N., Y. R. Santosh Laxmi, Rieger, R., and Shibutani, S. alpha-Hydroxylation of tamoxifen and toremifene by human and rat cytochrome P450 3A family enzymes. Chem. Res. Toxicol. 16. 1138-1144 (2003). PDF

Sanchez, A.M., Minko, I.G., Kurtz, A.J., Kanuri, M., Moriya, M. and Lloyd, R.S., Comparative evaluation of the bioreactivity and mutagenic spectra of acrolein-derived alpha-HOPdG and gamma-HOPdG regioisomeric deoxyguanosine adducts, Chem. Res. Toxicol. 16: 1019-1028. (2003) PDF

2002 Top

Tan, X., Suzuki, N., Grollman, A. P., and Shibutani, S. Mutagenic events in Escherichia coli and mammalian cells in response to acetylaminofluorene-derived DNA adducts positioned in the Nar I restriction enzyme site. Biochemistry 41, 14255-14262 (2002). PDF

Yang IY, Chan G, Miller H, Huang Y, Torres MC, Johnson F, Moriya M. Mutagenesis by acrolein-derived propanodeoxyguanosine adducts in human cells. Biochemistry. 2002 Nov 19;41(46):13826-32. PDF

Shibutani, S., Suzuki, N. and Grollman, A.P. Tamoxifen-DNA adducts: biomarkers for drug-induced endometrial cancer in Biomarkers of environmentally associated disease: technology, concepts and perspectives, ed by S.H. Wilson and W.A. Suk. CRC Press LLC, New York, 2002 pp 127-137 PDF

Zharkov, D.O.and Grollman A.P. Combining structural and bioinformatics methods for the analysis of functionally important residues in DNA glycosylases. Free Radic Biol. Med. 32:1254-63 (2002). PDF (394 K)

Suzuki, N., Ohashi, E., Kolbanovskiy, A., Geacintov, N.E., Grollman, A.P., Ohmori, H., and Shibutani, S. Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene). Biochemistry 41:6100-6 (2002) PDF (119 K)

Gilboa, R., Zharkov, D.O., Golan, G., Fernandes, A.S., Gerchman, S.E,, Matz, E., Kycia, J.H., Grollman, A.P., and Shoham, G. Structure of formamidopyrimidine-DNA glycosylase covalently complexed to DNA. J. Biol. Chem. 277:19811-6 (2002). PDF (618 K)

Yang, I.Y., Johnson, F., Grollman, A.P., and Moriya, M. Genotoxic mechanism for the major acrolein-derived deoxyguanosine adduct in human cells. Chem Res Toxicol. 15:160-4 (2002). PDF (63 K)

Zharkov, D.O., Golan, G., Gilboa, R., Fernandes, A.S., Gerchman, S.E., Kycia, J.H., Rieger, R.A., Grollman, A.P., and Shoham, G. Structural analysis of an Escherichia coli endonuclease VIII covalent reaction intermediate. EMBO J. 21:789-800 (2002). PDF (554 K)

Terashima I, Suzuki N, Shibutani S. 32P-Postlabeling/polyacrylamide gel electrophoresis analysis: application to the detection of DNA adducts. Chem. Res. Toxicol. 15:305-11 (2002). PDF (142 K)

Santosh Laxmi YR, Suzuki N, Dasaradhi L, Johnson F, Shibutani S. Preparation of oligodeoxynucleotides containing a diastereoisomer of alpha-(N(2)-2'-deoxyguanosinyl)tamoxifen by phosphoramidite chemical synthesis. Chem. Res. Toxicol.;15:218-25 (2002). PDF (149 K)

2001 Top

Shibutani, S., Suzuki, N., Tan, X., Johnson, F., and Grollman, A.P. Influence of flanking sequence context on the mutagenicity of acetylaminofluorene-derived DNA Adducts in mammalian cells. Biochemistry 40(12); 3717-3722 (2001). PDF(83Kb)

Yang, I-Y, Hossain, M., Miller, H., Khullar, S., Johnson, F., Grollman, A.P., and Moriya, M. Responses to the major acrolein-derived deoxyguanosine adduct in Escherichia coli. J. Biol. Chem. 276, 9071-9076 (2001). PDF

Levine, R.L., Miller, H., Grollman, A.P., Ohashi, E., Ohmori, H., Masutani, C., Hanoaka, F., and Moriya, M. Translesion DNA synthesis catalyzed by human pol h and pol k across 1,N6-ethenodeoxyadenosine. J. Biol. Chem. 276, 18717-18721 (2001) PDF

Shibutani, S., Ravindernath, A., Terashima, I., Suzuki, N., Santosh Laxmi, Y.R., Kanno, Y., Suzuki, M., Idil Apak, T., Sheng, J.J., and Duffel, M.W. Mechanism of lower genotoxicity of toremifene compared with tamoxifen. Cancer Res. 61, 3925-3931 (2001) PDF

Yasui, M., Matsui, S., Ihara, M., Santosh Laxmi, Y.R., Shibutani, S., and Matsuda, T. Translesional synthesis on a DNA template containing N2-methyl-2'-deoxyguanosine catalyzed by the Klenow fragment of Escherichia coli DNA polymerase I. Nucleic Acids Res. 29, 1994-2001 (2001) PDF

Terashima, I., Matsuda, T., Fan, T-W., Suzuki, N., Kobayashi, J., Kohda, K., and Shibutani, S. Miscoding potential of the N2-ethyl-2'-deoxyguanosine DNA adduct by the exonuclease-free klenow fragment of Escherichia coli DNA polymerase I. Biochemistry 40, 4106-4114 (2001) PDF

Terashima, I., Suzuki, N., and Shibutani, S. Mutagenic properties of estrogen-quinone-derived DNA adducts in simian kidney cells. Biochemistry 40, 166-172 (2001) PDF

2000 Top

Shibutani, S., Suzuki, N. and Grollman, A.P. Tamoxifen-DNA adducts: Biomarkers for drug-induced endometrial cancer. In: Progress in Nucleic Acid Research & Molecular Biology, Moldave, K. (Ed.), Academic Press, in press (2000).

Pandya, G.A., Yang, I-Y, Grollman, A.P., and Moriya, M. Escherichia coli responses to a single DNA adduct. J. Bacteriology 182, 6598-6604 (2000).PDF (272Kb)

Zharkov, D.O., Gilboa, R., Yagil, I., Kycil, J.H., Gerchman, S.E., Shoham, G., and Grollman, A.P. A role for lysine 142 in the excision of adenine from A:G mispairs by MutY DNA glycosylase of Escherichia coli. Biochemistry 39, 14768-14778 (2000).PDF(272Kb)

Levine, R.L., Yang, I.Y., Hossain, M., Pandya, G.A., Grollman, A.P. and Moriya, M. Mutagenesis induced by a single 1,N6-ethenodeoxyadenosine adduct in human cells. Cancer Res. 60, 4098-4104 (2000).PDF(264Kb)

Umemoto, A., Monden, Y., Suwa, M., Kanno, Y., Suzuki, M., Lin, C-X., Ueyama, Y., Abdul Momem, Md., Ravindernath, A., Shibutani, S., and Komaki, K. Identification of hepatic tamoxifen-DNA adducts in mice: a-(N2-deoxyguanosinyl)tamoxfen and a-(N2-deoxyguanosinyl)tamoxifen N-oxide. Carcinogenesis 21, 1737-1744 (2000) PDF

Shibutani, S., Reardon, J.T., Suzuki, N., and Sancar. A. Excision of tamoxifen-DNA adducts by the human nucleotide excision repair systems. Cancer Res. 60, 2607-2610 (2000).PDF(660Kb)

Zharkov, D.O., Rosenquist, T.A., Gerchman, S.E., and Grollman, A.P. Substrate specificity and reaction mechanisms of murine 8-oxoguanine-DNA glycosylases. J. Biol. Chem. 275, 28607-28617 (2000).PDF(255kb)

Shibutani, S., Ravindernath, A., Suzuki, N., Terashima, I., Sugarman, S.M., Grollman, A.P., and Pearl, M.L. Identification of tamoxifen-DNA adducts in the endometrium of women treated with tamoxifen. Carcinogenesis 21, 1461-1467 (2000).PDF(169Kb)

Rieger, R.A., McTigue, M.M., Kycia, J.H., Gerchman, S.E., Grollman, A.P., and Iden, C.R. Characterization of a cross-linked DNA-endonuclease VIII repair complex by electrospray ionization mass spectrometry. J. Am. Soc. Mass Spectrometry 11, 505-515 (2000).

Kitagawa, M., Ranindernath, A., Suzuki, N., Rieger, R., Terashima, I., Umemoto, A., and Shibutani, S. Identification of tamoxifen-DNA adducts induced by a-acetoxy-N-desmethyltamoxifen. Chem. Res. Toxicol. 13, 761-769 (2000) PDF

Conlon, K.A., Grollman, A.P., and Berrios, M. Immunolocalization of 8-oxoguanine in nutrient-deprived mammalian tissue culture cells. J. Histotechnology 23, 37-44 (2000).

Shibutani, S., Reardon, J.T., Suzuki, N., and Sancar, A. Exciswioni of tamoxifen-DNA adducts by the human nucleotide excision repair system. Cancer Res. 60, 2607-2610 (2000) PDF

Miller, H., Prasad, R., Wilson, S.H., Johnson, F. and Grollman, A.P. 8-OxoGTP incorporation by DNA polymerase beta is modified by active-site residue Asn279. Biochemistry 39, 1029-1033 (2000).PDF(106Kb)

1999Top

Moriya, M., Pandya, G.A., Johnson, F. and Grollman, A.P. Cellular response to exocyclic DNA adducts. In: Exocyclic DNA Adducts in Mutagenesis & Carcinogenesis. Singer, B. & Bartsch, H. (Eds.) IARC Scientific Publication (Lyon) 150, pp. 263-270 (1999).

Umemoto, A., Monden, Y., Komaki, K., Suwu, M., Kanno, Y., Suzuki, M., Lin, C.X., Ueyama, Y., Momen, M.A., Ravindernath, A., and Shibutani, S. Tamoxifen-DNA adducts formed by a-acetoxytamoxifen N-oxide. Chemical Research in Toxicology 12, 1083-1089 (1999).PDF(222Kb)

Tan, X., Suzuki, N., Grollman, A.P. and Shibutani, S. Comparison of the mutagenic properties of 8-oxo-7,8-dihydro-2'-deoxyadenosine and 8-oxo-7,8-dihydro-2'-deoxyguanosine DNA lesions in mammalian cells. Carcinogenesis 20, 2287-2292 (1999).PDF(138Kb)

Matsuda, T., Terashima, I., Matsumoto, Y., Yabushita, H., Matsui, S., and Shibutani, S. Effective utilization of N2-ethyl-2'-deoxyguanosine triphosphate during DNA synthesis catalyzed by mammalian replicative DNA polymerases. Biochemistry 38, 929-935 (1999).PDF(181Kb)

Terashima, I, Suzuki, N., and Shibutani, S. Mutagenic potential of a-N2-deoxyguanosinyl) tamoxifen lesions, the major DNA adducts detected in endometrial tissues of patients treated with tamoxifen. Cancer Res. 59, 2091-2095 (1999). PDF

Shibutani, S., Fernandes, A., Suzuki, N., Zhou, L., Johnson, F. and Grollman, A.P. Mutagenesis of the N-(Deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine DNA adduct in mammalian cells. J. Biol. Chem. 274, 27433-27438 (1999).PDF(198Kb)

Bonala, R.R., Rieger, R.A., Shibutani, S., Grollman, A.P., Iden, C.R. and Johnson, F. 3,N4-Ethano-2'-deoxycytidine: Chemistry of incorporation into oligomeric DNA and reassessment of miscoding potential. Nucleic Acids Res. 27, 4725-4733 (1999).PDF(445Kb)

Grollman, A.P. and Zharkov, D.O. Recognition and excision of bases from oxidatively damaged DNA by Fpg, Ogg1, and MutY proteins. In: Advances in DNA Damage and Repair. Oxygen Radical Effects, Cellular Protection and Biological Consequences. Dizdaroglu, M. and Karakaya, A.E. (Eds.), Plenum Publishers, NY, pp. 136-148 (1999). PDF

Shibutani, S., Suzuki, N., Terashima, I., Sugarman, S.M., Grollman, A.P. and Pearl, M.L. Tamoxifen-DNA adducts detected in endometrium obtained from patients treated with tamoxifen. Chem. Res. Toxicol. 12, 646-653 (1999).PDF(98Kb)

Deng, Y., Glimm, J., Wang, Y., Korobka, A., Eisenberg, M. and Grollman, A.P. Prediction of protein binding to DNA in the presence of water-mediated hydrogen bonds. J. Mol. Model. 5, 125-133 (1999).

Tan, X., Suzuki, N., Johnson, F., Grollman, A.P. and Shibutani, S. Mutagenic properties of the 8-amino-2'-deoxyguanosine DNA adduct in mammalian cells. Nucleic Acids Res. 27, 2310-2314 (1999).PDF(90Kb)

Grollman, A.P., Moriya, M., Shibutani, S . and Takeshita, M. Endogenous DNA damage, mutagenesis, and aging. In: Molecular Biology of Aging. Alfred Benzon Symposium 44. Bohr, V.A., Clark, B.F.C., Stevnsner, T. (Eds.), Munksgaard, Copenhagen, pp. 191-201 (1999).

1998Top

Shibutani, S., Dasaradhi, L., Terashima, I., Banoglu, E., and Duffel, M.W. Alpha-hydroxytamoxifen is a substrate of hydroxysteroid (alcohol) sulfotransferase, resulting in tamoxifen DNA adducts. Cancer Research 58, 647-653 (1998).

Terashima, I., Suzuki, N., Itoh, S., Yoshizawa, I., and Shibutani, S. Mutagenic specificity of model estrogen-DNA adducts in mammalian cells. Biochemistry 37, 8803-8807 (1998).PDF(112Kb)

Terashima, I., Suzuki, N., Dasaradhi, L., Tan, C.K., Downey, K.M., and Shibutani, S. Translesional synthesis on DNA templates containing an estrogen quinone-derived adduct: N2-(2-hydroxyestron-6-yl)-2'-deoxyguanosine and N6-(2-hydroxyestron-6-yl)-2'-deoxyadenosine. Biochemistry 37, 13807-13815 (1998).PDF(228Kb)

Shibutani, S., Shaw, P.M., Suzuki, N., Dasaradhi, L., Duffel, M.W., and Terashima, I. Sulfation of alpha-hydroxytamoxifen catalyzed by human hydroxysteroid sulfotransferase results in tamoxifen-DNA adducts. Carcinogenesis 19, 2007-2011 (1998). PDF (180Kb)

Itoh, S., Hirai, T., Totsuka, Y., Takagi, H., Tashiro, Y., Wada, K., Wakabayashi, K., Shibutani, S., and Yoshizawa, I. Identification of estrogen-modified nucleosides from calf thymus DNA reacted with 6-hydroxyestrogen 6-sulfates. Chem. Res. Toxicol. 11, 1312-1318 (1998).PDF(189Kb)

Shibutani, S., Fernandes, A., Suzuki, N., Zhou, L., Johnson, F. and Grollman, A.P. Site-specific mutagenesis of the N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine DNA adduct in mammalian cells. Z. Lebensm Unters Forsch A 207, 459-463 (1998).

Gelfand, C.A., Plum, G.E., Grollman, A.P., Johnson, F. and Breslauer, K.J. Thermodynamic consequences of an abasic leslion in duplex DNA are strongly dependent on base sequence. Biochemistry 37, 7321-7327 (1998).PDF(61Kb)

Gelfand, C.A., Plum, G.E., Grollman, A.P., Johnson, F. and Breslauer, K.J. The impact of an exocyclic cytosine adduct on DNA duplex properties: Signficant thermodynamic consequences despite modest lesion-induced structural alterations. Biochemistry 37, 12507-12512 (1998).PDF(105Kb)

Lin, Z., Hung, K.-N., Grollman, A.P. and de los Santos, C. Solution structure of duplex DNA containing an extrahelical abasic site analog determined by NMR spectroscopy and molecular dynamics. Nucleic Acids Res. 26, 2385-2391 (1998).PDF(143Kb)

Terasmina, I., Suzuki, N., Dasaradhi, L., Tan, C.K., Downey, K.M., and Shibutani, S. Translesional synthesis on DNA templates containing an estrogen quinone-derived adduct: N2-(2-hydroxyestron-6-yl)-2'-deoxyadenosine. Biochemistry 37, 13807-13815 (1998) PDF

Zharkov, D.O. and Grollman, A.P. MutY DNA glycosylase: base release and intermediate complex formation. Biochemistry 37, 12384-12394 (1998).PDF(149Kb)

Shibutani, S., Suzuki, N. and Grollman, A.P. Mutagenic specificity of acetylaminofluorene-derived DNA adducts in mammalian cells. Biochemistry 37, 12034-12041 (1998).PDF(278Kb)

Fernandes, A., Liu, T., Amin, S., Geacintov, N.E., Grollman, A.P. and Moriya, M. Mutagenic potential of stereo- isomeric bay region (+)- and (B)-cis-anti-benzo[a]pyrene diol expoxide-N2-deoxyguanosine adducts in Eschericia coli and simian kidney cells. Biochemistry 37, 10164-10172 (1998).PDF(145Kb)

Gening, L., Takeshita, M., Levine, R.L., Peden, K.W. and Grollman, A.P. Extrachromosomal unequal homologus recombination and gene conversion in simian kidney cells: Effects of UVdamage. Mutation Res. 407, 11-24 (1998).

1997Top

Shibutani, S., Itoh, S., and Yoshizawa, I. Miscoding properties of model estrogen-DNA adducts in reactions catalyzed by mammalian and Escherichia coli DNA polymerases. Biochemistry 36, 1755-1765 (1997).PDF(401Kb)

Dasaradhi, L. and Shibutani, S. Identification of tamoxifen-DNA adducts formed by _-sulfate tamoxifen and _-acetoxytamoxifen. Chem. Res. Toxicol. 10, 189-196 (1997).PDF(619Kb)

Mozzherin, D.J., Shibutani, S., Tan, C.K., Downey, K.M., and Fisher, P.A. Proliferating cell nuclear antigen promotes DNA synthesis past template lesions by mammalian DNA polymerase . Proc. Natl. Acad. Sci. USA 94, 6126-6131 (1997).PDF(448Kb)

Kohda, K., Tsunomoto, H., Kasamatsu, T., Sawamura, F., Terashima, I., and Shibutani, S. Synthesis and miscoding specificity of oligodeoxynucleotide containing 8-phenyl-2'-deoxyguanosine. Chem. Res. Toxicol 10, 1351-1358 (1997).PDF(356Kb)

Shibutani, S. and Dasaradhi, L. Miscoding potential of tamoxifen-derived DNA adducts: _-(N2-deoxy guanosinyl)tamoxifen. Biochemistry 36, 13010-13017 (1997).PDF(469Kb)

Miller, H. and Grollman, A.P. Kinetics of DNA polymerase I (Klenow fragment exo-) activity on damaged DNA templates: Effect of proximal and distal template damage on DNA synthesis. Biochemistry 36, 15336-15342 (1997).PDF(121Kb)

Rosenquist, T., Zharkov, D.O. and Grollman, A.P. Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase. Proc. Natl. Acad. Sci. USA 94, 7429-7434 (1997).PDF(374Kb)

Shibutani, S. and Grollman, A.P. Molecular mechanisms of mutagenesis by aromatic amines and amides. Mutation Res. 376, 71-78 (1997).

Shibutani, S., Takeshita, M., and Grollman, A.P. Translesional synthesis on DNA templates containing a single abasic site: A mechanistic study of the "A rule". J. Biol. Chem. 272, 13916-13922 (1997).PDF(347Kb)

Zharkov, D., Rieger, R.A., Iden, C.R. and Grollman, A.P. NH2-terminal proline acts as a nucleophile in the glycocylase/AP lyase reaction catalyzed by Escherichia coli formamidopyrimidine-DNA glycosylase (Fpg) protein. J. Biol. Chem. 272, 5335-5341 (1997).PDF(280Kb)

Cullinan, D., Johnson, F., Grollman, A.P., Eisenberg, M. and de los Santos, C. Solution structure of a DNA duplex containing the exocyclic lesion 3,N⁴-etheno-2'-deoxycytidine opposite 2-deoxyguanosine. Biochemistry 36, 11933-11943 (1997).PDF(432Kb)

Karakaya, A., Jaruga, P., Bohr, V.A., Grollman, A.P., and Dizdaroglu, M. Kinetics of excision of purine lesions from DNA by fpg protein. Nucleic Acids Res. 25, 474-479 (1997).PDF(93Kb)

Mozzherin, D. Ju, Shibutani, S., Tan, C-K., Downey, K.M., and Fisher, P.A. Proliferating cell nuclear antigen promotes DNA synthesis past template lesions by mammalian DNA polymerase d. Proc. Natl. Acad. Sci. USA 94, 6126-6131 (1997) PDF

1996Top

Chen, H., Johnson, F., Grollman, A.P., and Patel, D.J. Structural studies of the ionizing radiation adduct 7,8-dihydro-8-oxoadenine (A^oxo) positioned opposite thymine in a DNA duplex. Magnetic Resonance in Chemistry 34, S23-S32 (1996).

Shibutani, S., Suzuki, N., Matsumoto, Y. and Grollman, A.P. Miscoding properties of 3,N⁴-etheno-2'-deoxycytidine in reactions catalyzed by mammalian DNA polymerases. Biochemistry 35, 14992-14998 (1996).PDF(602Kb)

Grollman, A.P. and Takeshita, M. 8-Oxoguanine and bistrand abasic sites in DNA: Mutagenic potential and repair. In: 1895-1995 Congress Proceedings Vol. 2. Hagen, U., Harder, D., Jung, H., and Streffer, C. (Eds.), pp. 316-319 (1996).

Greenblatt, M.S., Grollman, A.P., and Harris, C.C. Deletions and insertions of p53 tumor suppressor gene in human cancers: Confirmation of the DNA polymerase slippage/misalignment model. Cancer Res. 56, 2130-2136 (1996).

Cullinan, D., Korobka, A., Grollman, A.P., Patel, D.J., Eisenberg, M., and de los Santos, C. NMR solution structure of an oligodeoxynucleotide duplex containing the exocyclic lesion 3,N⁴-ethenodeoxycytosine opposite thymine: comparison with the duplex containing deoxyadenosine opposite the adduct. Biochemistry 35, 13319-13327 (1996).PDF(506Kb)

Korobka, A., Cullinan, D., Cosman, M., Grollman, A.P., Patel, D.J., Eisenberg, M., and de los Santos, C. Solution structure of an oligodeoxynucleotide duplex containing the exocyclic lesion 3,N⁴-ethenodeoxycytosine opposite deoxyadenine, determined by NMR spectroscopy and restrained molecular dynamics. Biochemistry 35, 13310-13318 (1996).PDF(469Kb)

Gelfand, C.A., Plum, G.E., Grollman, A.P., Johnson, F., and Breslauer, K.J. The impact of a bistrand abasic lesion on DNA duplex properties. Biopolymers 38, 439-445 (1996).

Bulychev, N.V., Varaprasad, C.V., Dorman, G., Miller, J.H., Eisenberg, M., Grollman, A.P. and Johnson, F. Substrate specificity of E. coli muty protein. Biochemistry 35, 13147-13156 (1996).PDF(630Kb)

Campbell, G., Deng, Y., Glimm, J., Yu, Q., Eisenberg, M. and Grollman, A.P. Analysis and prediction of protein binding on DNA: Pattern recognition of hydrogen bonds. J. Computational Chemistry 17, 1712-1725 (1996).

Moriya, M., Spiegel, S., Fernandes, A., Amin, S., Liu, T.-M., Geacintov, N.E. and Grollman, A.P. Fidelity of translesional synthesis past benzo[a]pyrene diol epoxide-2 deoxyguanosine DNA adducts: Marked effects of host cell, sequence context, and chirality. Biochemistry 35, 16646-16651 (1996).PDF(382Kb)

Kohda, K., Tsunomoto, H., Minoura, Y., Tanabe, K., and Shibutani, S. Synthesis, miscoding specificity, and thermodynamic stability of oligodeoxynucleotide containing 8-methyl-2'-deoxyguanosine. Chem. Res. Toxicol. 9, 1278-1284 (1996) PDF

Varaprasad, C.V., Bulychev, N., Grollman, A.P. and Johnson, F. Synthesis of 8-oxo-7,8-dihydro-6-O-methyl-2'-deoxyguanosine and its use as a probe to study DNA-base excision by mutY enzyme. Tetrahedron Letters 37, 9-12 (1996).

1995Top

LePage, F., Margot, A., Grollman, A.P., Sarasin, A., and Gentil, A. Mutagenicity of a unique 8-oxoguanine in a human Ha-ras sequence in mammalian cells. Carcinogenesis 16, 2779-2784 (1995).

Plum, G.E., Grollman, A.P., Johnson, F. and Breslauer, K.J. Influence of the oxidatively damaged adduct 8-oxodeoxyguanosine on the conformation, energetics, and thermodynamic stability of a DNA duplex. Biochemistry 34, 16148-16160 (1995).

Grollman, A.P. and Takeshita, M. Miscoding and mutagenic properties of 8-oxoguanine and abasic sites: Ubiquitious lesions in damaged DNA. In: Radiation Damage to DNA: Structure/Function Relationship of Early Times. Fuciarelli, A.F. and Zimbrick, J.D. (Eds.), Batelle Press, Columbus, Ohio, pp. 293-304 (1995).

Tchou, J. and Grollman, A.P. The catalytic mechanism of Fpg protein: Evidence for a Schiff base intermediate and amino-terminus localization of the catalytic site. J. Biol. Chem. 270, 11671-11677 (1995).PDF (1.3Mb)

Wilson, D.M. III, Takeshita, M., Grollman, A.P. and Demple, B. Incision activity of human apurinic endonuclease (Ape) at abasic site analogs in DNA. J. Biol. Chem. 270, 16002-16007 (1995).HTML

Grollman, A.P. 8-Oxoguanine in DNA: Its mutagenic properties and repair. Environ. Mut. Res. Commun. 16, 239-243 (1995).

Zhang, W., Johnson, F., Grollman, A.P. and Shibutani, S. Miscoding by the exocyclic DNA adducts: 3,N⁴-ethano-2'-deoxycytidine and 3-(2-hydroxyethyl)-2'-deoxyuridine. Chem. Res. Toxicol. 8, 157-163 (1995)

Pinz, K., Shibutani, S., and Bogenhagen, D. Action of mitochondrial DNA polymerase g at sites of base loss or oxidative damage. J. Biol. Chem. 270, 9202-9606 (1995).

1994Top

Moriya, M., Zhang, W., Johnson, F. and Grollman, A.P. Mutagenic potency of exocyclic DNA adducts: Marked differences between Escherichia coli and simian kidney cells. Proc. Natl. Acad. Sci. USA 91, 11899-11903 (1994).PDF(1Mb)

Shibutani, S. and Grollman, A.P. Miscoding during DNA synthesis on damaged DNA templates catalyzed by extracts prepared from mammalian cells. Cancer Letters 83, 315-322 (1994).

Grollman, A.P., Johnson, F., Tchou, J., and Eisenberg, M. Recognition and repair of 8-oxoguanine and formamidopyrimidine lesions in DNA. In: Annals of New York Academy of Sciences Vol. 726. Wallace, S.S. VanHouten, B., and Kow, Y.W. (Eds.), pp. 208-214 (1994). PDF

Tchou, J., Bodepudi, V., Shibutani, S., Antoshechkin, I., Miller, J., Grollman, A.P. and Johnson, F. Substrate specificity of Fpg protein: Recognition and cleavage of oxidatively damaged DNA. J. Biol. Chem. 269, 15318-15324 (1994). PDF

1993Top

Kasai, H., Chung, M.H., Yamamoto, F., Ohtsuka, E., Laval, J., Grollman, A.P. and Nishimura, S. Formation, inhibition of formation, and repair of oxidative 8-hydroxyguanine DNA damage (review). Basic Life Sciences 61, 257-262 (1993).

Shibutani, S. and Grollman, A.P. Nucleotide misincorporation of DNA templates containing N-(deoxyguanosin-N²-yl)-2-acetylaminofluorene (dG-N²-AAF). Chem. Res. Toxicol. 6, 819-824 (1993).

Tchou, J., Michaels, M.L., Miller, J.H. and Grollman, A.P. Function of the zinc finger domain in Escherichia coli Fpg protein. J. Biol. Chem. 268, 26738-26744 (1993). PDF

Grollman, A.P. and Shibutani, S. Mutagenic specificity of chemical carcinogens as determined by studies with single DNA adducts. In: DNA Adducts: Identification and Biological Significance. Hemminki, K., Dipple, A., Shuker, D., Kadlubar, F.F., Segerback, D. and Bartsch, H. (Eds.), IARC Scientific Publications No. 125, Lyon, France (1993).

Moriya, M. and Grollman, A.P. Mutations of the mutY gene of Escherichia coli enhance the frequency of targeted G:C_T:A transversions induced by a single 8-oxoguanine residue in single-stranded DNA. Molecular Gen. Genet. 239, 72-76 (1993).

Moriya, M. Single-stranded shuttle phagemid for mutagenesis studies in mammalian cells: 8-oxoguanine in DNA
induces targeted G.C-->T.A transversions in simian kidney cells. Proc. Natl. Acad. Sci. USA 90, 1122-1126 (1993).

Shibutani, S. and Grollman, A.P. On the mechanism of frameshift (deletion) mutagenesis in vitro. J. Biol. Chem. 268, 1703-11710 (1993).

Grollman, A.P. and Moriya, M. Mutagenesis by 8-oxoguanine: An enemy within. Trends in Genetics 9, 246-249 (1993). PDF

Shibutani, S., Margulis, L.A., Geacintov, N.E. and Grollman, A.P. Translesional synthesis on DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene). Biochemistry 32, 7531-7541 (1993).

Tchou, J. and Grollman, A.P. Repair of DNA containing the oxidatively-damaged base, 8-oxoguanine. Mutation Res. 299, 277-287 (1993). PDF

Shibutani, S., Bodepudi, V., Johnson, F. and Grollman, A.P. Translesional synthesis on DNA templates containing 8-oxo-7,8-dihydrodeoxyadenosine. Biochemistry 32, 4615-4621 (1993).

Shibutani, S. Quantitation of base substitutions and deletions induced by chemical mutagens during DNA synthesis in vitro. Chem. Res. Toxicol. 5, 625-629 (1993).

1992Top

Plum, G.E., Grollman, A.P., Johnson, F. and Breslauer, K.J. Influence of an exocyclic guanine adduct on the thermal stability, conformation, and melting thermodynamics of a DNA duplex. Biochemistry 31, 12096-12102 (1992).

Michaels, M.L., Tchou, J., Grollman, A.P. and Miller, J.H. A repair system for 8-oxo-7,8-dihydrodeoxyguanine (8-hydroxyguanine). Biochemistry 31, 10964-10968 (1992).

Michaels, M.L., Cruz, C., Grollman, A.P. and Miller, J.H. Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA. Proc. Natl. Acad. Sci. USA 89, 7022-7025 (1992).PDF(1.1Mb)

Grollman, A.P. Structural basis for the mutagenic specificity of 8-oxoguanine-DNA. In: Proceedings of the Seventh Conversation in Biomolecular Stereodynamics. Sarma, R. (Ed.), Adenine Press (1992).

Bodepudi, V., Shibutani, S., and Johnson, F. Synthesis of 2'-deoxy-7,8-dihydro-8-oxoguanosine and 2'-deoxy-
7,8-dihydro-8-oxoadenosine and their incorporation into oligomeric DNA. Chem. Res. Toxicol. 5, 608-617 (1992).

1991Top

Kalman, T.I., Marinelli, E.R., Xu, B., Benugopala Reddy, A.R., Johnson, F. and Grollman, A.P. Inhibition of cellular thymidylate synthesis by cytotoxic propenal derivatives of pyrimidine bases and deoxynucleosides. Biochemical Pharmacology 42, 432-437 (1991).

Tchou, J., Kasai, H., Shibutani, S., Chung, M.H., Laval, J., Grollman, A.P., and Nishimura, S. 8-Oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity. Proc. Natl. Acad. Sci. USA 88, 4690-4694 (1991).PDF(2Mb)

Moriya, M., Ou, C., Bodepudi, V., Johnson, F., Takeshita, M. and Grollman, A.P. Site-specific mutagenesis using a gapped duplex vector: A study of in vivo translesion synthesis past 8-oxodeoxyguanine. Mutation Res. 254, 281-288 (1991).

Shibutani, S., Gentles, R., Johnson, F. and Grollman, A.P. Isolation and characterization of oligodeoxynucleotides containing dG-N²-AAF and oxidation products of dG-C8-AF. Carcinogenesis 12, 813-818 (1991).

Kouchakdjian, M., Eisenberg, M., Johnson, F., Grollman, A.P., and Patel, D.J. Structural features of an exocyclic adduct positioned opposite an abasic site in a DNA duplex. Biochemistry 30, 3262-3270 (1991).

Kouchakdjian, M., Bodepudi, V., Shibutani, S., Eisenberg, M., Johnson, F., Grollman, A.P., and Patel, D.J. NMR structural studies of the ionizing radiation adduct 8-oxodeoxyguanosine (8-oxodG) opposite deoxyadenosine in a DNA duplex. 8-OxodG(syn):dA(anti) alignment at lesion site. Biochemistry 30, 1403-1412 (1991).

Shibutani, S., Takeshita, M. and Grollman, A.P. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature 349, 431-434 (1991).

Chen, Y.H., Matsumoto, Y., Shibutani, S., and Bogenhagen, D.F. Acetylaminofluorene and aminofluorene adducts inhibit in vitro transcription of a Xenopus 5S RNA gene only when located on the coding strand. Proc. Natl. Acad. Sci. USA 88, 9583-9587 (1991).

1990Top

Kouchakdjian, M., Eisenberg, M., Live, D., Marinelli, E., Grollman, A.P. and Patel, D.J. NMR studies of an exocyclic 1,N²-propanodeoxyguanosine adduct (X) located opposite deoxyadenosine (A) in DNA duplexes at basic pH: Simultaneous partial intercalation of X and A between stacked bases. Biochemistry 29, 4456-4465 (1990).

Grollman, A.P. Site specific mutagenesis. In: Fifth International Conference on Environmental Mutagens.
Mendelsohn, M.L. (Ed.), Alan R. Liss, New York (1990)

 

 

 

 

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