Molecular Pharmacology of Tumor and Virus Inhibitors (NCI) (A.P. Grollman, PI). Research designed to elucidate molecular mechanisms by which enzymes recognize, repair, and catalyze translesion synthesis past endogenous and exogenous damage in DNA.

Cellular Response to DNA Adducts (NCI) (M. Moriya, PI). The objective of this research program is to explore molecular mechanisms of mutagenesis and damage tolerance.

Mutational Properties of DNA Adducts Derived from Estrogens and Anti-Estrogens (NIEHS) (S. Shibutani, PI). The goals of this research are to establish the genotoxic mechanism of tamoxifen and to identify safe drugs for use in the chemoprevention of breast cancer.

Molecular Toxicology of DNA Adducts (NIEHS) (A.P. Grollman, PI). Research supported by this program project centers on DNA damage produced by environmental mutagens and its biological consequences. Project directors include Drs. Shinya Shibutani, Thomas Rosenquist, Francis Johnson, and Charles Iden.

Exocyclic DNA Adducts and Oxidative DNA Damage (NCI) (A.P. Grollman, PI). This program project explores relationships among molecular structure, thermodynamics, and biological function. An organic chemist (Francis Johnson), physical chemists (Kenneth J. Breslauer, Carlos de los Santos, and Charles Iden), and molecular biologists (Masaaki Moriya, and Arthur Grollman) collaborate to explore DNA damage recognition and mechanisms of DNA repair. 

Etiology of Balkan Endemic Nephropathy (Fogarty Center) (A.P. Grollman, P.I.). This research is designed to identify the environmental toxin responsible for endemic nephropathy and its associated urothelial cancer. The lead foreign investigator is Bojan Jelakovic.

Other Support

The Laboratory for Chemical Biology receives support from SUNY, and from the endowment established by Mrs. Evelyn Glick of Baltimore, MD. The Laboratory gratefully acknowledges the generous gifts of Mr. and Mrs. Leo Zickler, and Mrs. Arline Lubin.